PSUN115 Features of Metabolic and Hemodynamic Parameters in Obese Patients with True and Pseudo-Resistant Hypertension

Abstract Given the negative contribution of obesity-associated metabolic disorders to formation cardiovascular complications, adequate blood pressure (BP) control is very important in patients with arterial hypertension (AH) and obesity comorbidity. Objective conduct a comparative assessment between hemodynamic parametersinobese true pseudo-resistant AH. Methods The study included 302 uncontrolled AH obesity. Initial treatment efficacy was assessed 3 months after dual therapy administered. Those who did not reach target BP were transferred triple therapy. Among received therapy, 69 people (they fourth drug spironolactone). All additionally examined 6 initiation antihypertensive Results A levels carried out non-resistant resistant patients: at initial stage enrolling patients, there no significant difference subsequently patients; follow-up (after prescribing double fixed combinations), indicators both office out-of-office resistance non-resistance; despite achievement presence resistance, office, home most ABPM significantly higher than non-resistance. An possible causes pseudo-resistance showed that often, observed non-compliance recommendations increase physical activity (55.26%) reduce calorie intake food consumed (44.77%), as well poor compliance prescribed (42.11%). At same time, high salt intake, chronic kidney disease, obstructive sleep apnoea, white-coat phenomenon also contributed pseudo-resistance. More half (63.16%) had combination several factors could contribute If into start then SBP (p<0.01) 24 h average according data (p<0.05) compared patients. Obese lower BMI LDL-cholesterol aldosterone Conclusions Even when are achieved, obese characterized by BP, Compared pseudo-resistance, associated aldosteron levels, LDL-cholesterol. Presentation: Sunday, June 12, 2022 12:30 p.m. - 2:30